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MAK Commission: Ethylene oxide - Method for the determination of ethylene oxide in workplace air using gas chromatography after solvent desorption

Air Monitoring Method

This analytical method is a validated measurement procedure for the determination of ethylene oxide [75-21-8] in workplace air averaged over the sampling period after personal or stationary sampling. Sampling is performed by drawing air through a tube filled with activated charcoal. The flow is set to 25 ml/min with a recommended air sample volume of 6 l. Sampling is performed over 40 min. The adsorbed ethylene oxide is desorbed using a toluene/carbon disulphide mixture (90+10 v/v) and converted to 2-bromoethanol using hydrobromic acid after the phases have separated and been filtered. The sample is analysed by means of gas chromatography (GC) with a mass selective detector (MSD). The quantitative evaluation is based on a calibration function obtained by means of a multiple-point calibration. The relative limit of quantification (LOQ) is 7 μg/m³ ethylene oxide for an air sample volume of 6 l. The mean recovery was 94% and the expanded uncertainties were between 20 and 21%.

Bibliographic information

W. Krämer, T. H. Brock, R. Hebisch, A. Hartwig:
MAK Commission: Ethylene oxide - Method for the determination of ethylene oxide in workplace air using gas chromatography after solvent desorption. Air Monitoring Method
in: The MAK Collection for Occupational Health and Safety, Vol 7, No 1 2022. pages 1-8, DOI: 10.34865/am7521be7_1or

download file "MAK Commission: Ethylene oxide - Method for the determination of ethylene oxide in workplace air using gas chromatography after solvent desorption" (PDF, 467 KB, Not barrier-free file)

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