In this research project, a new OECD Test Guideline (TG) for the determination of "Particle Size and Particle Size Distributions of Nanomaterials" was developed as the existing OECD TG 110 is considered to be outdated in terms of applicable size range (not covering sizes <200 nm) and methods. By its scope with an applicable size range from 1 to 1000 nm the new Test Guideline (TG PSD) covers the whole nanoscale. The TG PSD is applicable for particulate and fibrous nanomaterials. The prescribed, pairwise measurement of fibre diameter and length in the TG PSD allows for the first time to differentiate fibres with regard to their size-dependent hazard properties. Measurement instructions for each included method were validated within two separated interlaboratory comparisons, as a distinction between near spherical particles and fibres when applying the methods has to be made.
Besides information on content and structure of the TG PSD, this final report outlines essential steps, considerations and organisational aspects during the development of the TG. Insights into the selection, preparation and prevalidation of test materials used in the interlaboratory comparison are given. Finally, main results of the interlaboratory comparisons and their impacts on the TG PSD are presented.
The Publication "Development of a specific OECD Test Guideline on Particle Size and Particle Size Distribution of Nanomaterials" can be purchased at the website of the Umweltbundesamt (UBA).
A. Schmidt, H. Bresch, K. Kämpf, V. Bachmann, T. Peters, T. A. J. Kuhlbusch:
Development of a specific OECD Test Guideline on Particle Size and Particle Size Distribution of Nanomaterials. Final Report
Dessau-Roßlau: Umweltbundesamt 2021. pages 47, Project number: F 2428
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