The aim of the project is the development of an effect-based test system for the assessment of the inhalation toxicity of mold-induced biogenic particles for practical application.
In this project, different effect-related analyzes (vitality, immune response) with representative molds often detected in contaminated rooms are to be carried out by in-vitro methods. A variety of molds with known toxin formation are used to validate the test system. The extraction of the molds and their metabolic compounds is carried out from different inoculated organic starting materials. The extraction methods for the subsequent detection of toxic effects in the in vitro model represent an essential aspect for the project objective, which will be investigated in detail. The project is performed on behalf of the Federal Environment Agency (UBA) (departmental research plan 2018).
Unit 4.7 "Biological Agents"