The derivation and setting of occupational exposure limit values is an important component of the risk assessment and risk management of chemicals in different national as well as international processes. On the EU level the harmonisation of airborne exposure limit values is a current issue, because for some substances different limit values for workplaces were yielded by occupational safety and health legislation on the one hand and by chemicals legislation on the other hand.
The objective of this project is to disclose the differences between the current methods for the derivation of limit values and the resulting differences in protection levels. To achieve this, distributions of single extrapolation factors, which are necessary for bridging data gaps in the process of deriving limit values, as well as combinations of these distributions, are to be determined on the basis of updated empirical data. The overarching aim is to develop a common understanding of the necessary definitions in the setting of limit values and in this way to build a basis for a harmonisation of the derivation of occupational exposure limit values in the EU.
Unit 4.3 "Toxicology"