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Occupational risk factors for cardiovascular diseases - prospective analysis of the Gutenberg-Health-Study (GHS)

Project number: F 2338 Institution: Federal Institute for Occupational Safety and Health (BAuA) / University Mainz / TU Dresden Status: Ongoing Project Planned end: 2019-07-31


People in western industrialized nations die more frequently due to heart attack and stroke than for all forms of cancer and AIDS. Cardiovascular diseases (CVD) are responsible for approximately 10% of early retirement, and a quarter of all premature deaths in the labor force. The Gutenberg Health Studies (GHS) is a currently running cohort study including 15,000 primary healthy people. The primary target of the study is to improve risk prediction for selected diseases. Medical data, cardiovascular biomarkers (eg, lipids, and DNA and protein patterns) and vascular functions (endothelial function) are considered. Under occupational health aspect the occupational biography, including the night shift and overtime history are collected. The baseline examination of the cohort study took place from April 2007 to April 2012. The 2nd follow-up began 5 years after the start of the baseline survey (from 30 April 2012) with a clinical examination and survey of all originally included subjects. The primary objective of the ongoing project is to find associations between specific occupational factors at baseline and new onset of CVD and / or changes of cardiovascular biomarkers 5 years after the baseline examination. Exposures to occupational factors (eg night shifts) are considered as predictors for the occurrence of events, as well as sub-clinical and clinical conditions at 2. Follow-up time. Relative risks for CVD due to occupational exposures will be calculated.


Unit 3.1 "Prevention of Work-related Diseases"

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