Toxic effects of different modifications of a nanoparticle after inhalation
The toxicity of nanoparticles is an issue relevant for occupational health. The available data indicate that the smaller the particle the higher the toxicity. On the other hand, there is a lack of scientific information how surface properties modify particle toxicity.The project aims at studying a specific nanoparticle in unchanged and in two surface-modified versions, respectively. The project studies the im pact of surface modifications on the toxicological properties. The experimental set-up will be a 28-day inhalation study according to method b.8 of EC/440/2008 (i.e. OECD 412) in extended form. It is intended to include a 90-d post observation period be able to study the course of selected toxicity markers which describe the toxicological profile of the nanoparticles under consideration.
Unit 4.3 "Toxicology"