The toxicity of nanoparticles is an issue relevant for occupational health. The available data indicate that the smaller the particle the higher the toxicity. On the other hand, there is a lack of scientific information how surface properties modify particle toxicity.The project aims at studying a specific nanoparticle in unchanged and in two surface-modified versions, respectively. The project studies the im pact of surface modifications on the toxicological properties. The experimental set-up will be a 28-day inhalation study according to method b.8 of EC/440/2008 (i.e. OECD 412) in extended form. It is intended to include a 90-d post observation period be able to study the course of selected toxicity markers which describe the toxicological profile of the nanoparticles under consideration.
Unit 4.3 "Toxicology"