In an ongoing large cohort study in Mainz (Gutenberg Heart Study, including n=15,000 probands aged 25 to 74), an in-depth analysis of work-related risk factors for cardiovascular diseases is planned. The aim of the study is to examine the relationship between psychosocial workload and arterial hypertension; psychosocial workload is assessed by the Copenhagen Psychosocial Questionnaire (COPSOQ) and by the Effort-Reward-Imbalance (ERI) instrument (developed by Siegrist). Furthermore, the relationship between cumulative duration of night shift work and cardiovascular diseases will be examined taking confounding as well as potential effect modification into consideration. As additional outcomes, heart rate variability and Diabetes mellitus are considered.
The Gutenberg Heart Study will at first be analyzed as a cross-sectional study. Later, in a longitudinal analysis, incidence rate ratios will be calculated for the relationship between work-related risk factors and cardiovascular morbidity and mortality.
Unit 3.1 "Prevention of Work-related Diseases"